POS0081 CLINICAL FEATURES OF PEDIATRIC BEHÇET’S DISEASE IN CHINA

Background: Behçet’s disease (BD) is a systemic inflammatory involving primarily the oral and genital mucosa, skin eyes. Some patients exhibit broader involvement with multi-organ system inflammation, causing significant morbidity mortality. With much of literature focused on adult-onset BD, clinical spectrum BD in children not well studied. The diagnosis pediatric difficult to make due its rarity childhood, paucity experience among pediatricians lack validated diagnostic criteria. Objectives: We aim describe characteristic China. Methods: performed cross-sectional cohort analysis recruited between June 2017 May 2020. enrolled total 848 (onset prior age 18 years) 1531 BD. Clinical data were collected by retrospective chart review. Results: From (412 males, 436 females), average onset was 11.59 ± 4.11 years earliest case appeared first symptom at 7 months age. manifestations this group included recurrent aphtosis (100%), ulcers (77.71%), ocular (30.19%), (63.56%), neurological (4.60%), gastrointestinal (20.05%), vascular (9.79%), heart valve (3.66%), arthritis / arthralgia (32.43%), fever (0.35%) positive pathergy test (21.11%; Table 1). prevalence these findings largely similar that adult exception mild differences frequency gastrointestinal, valve, joint fever. However, time from significantly longer compared adults (13.34±9.13 vs. 6.73±33.21 years, P<0.001). most common initial (91.57% 86.28% adults, In group, also differed males females. addition ulcers, male (42.23%), (15.53%), (5.10%) epididymitis (9.95%). Among female patients, higher than men (86.24% 68.69%, Conclusion: described characteristics large While are delayed patients. Our study highlights need improve awareness providers facilitate rapid treatment children. References: [1]Yildiz et al. Pediatric disease- aspects current concepts. Eur J Rheumatol 2020; 7(Suppl 1): S38-S47. [2]Koné-Paut. children, an overview. Rheumatology (2016) 14:10. 1. Comparison features Children (n=848) Adult (n=1531) P Age (y) 11.59±4.11 27.08±7.91 Sex(M/F) 412/436 Years 13.34±9.13 <0.001 Recurrent aphthosis (100%) 1518 (99.15%) 0.007 Genital Ulcers 659 (77.71%)189 1152 (75.24%)379 0.176 Ocular signs 256 (30.19%)592 508 (33.18%)1023 0.134 Cutaneous 539 (63.56%)309 1020 (66.62%)511 0.132 Neurological 39 (4.60%)809 82 (5.36%)1449 0.421 Gastrointestinal 170 (20.05%)678 244 (15.94%)1387 0.001 Vascular 83 (9.79%)765 162 (10.58%)1369 0.542 Heart 31 (3.66%)817 110 (7.18%)1421 Joint 275 (32.43%)573 612 (39.97%)919 Fever 3 (0.35%)845 22 (1.44%)1509 0.013 Positive 179 (21.11%)669 347 (22.66%)1184 0.381 Acknowledgements: China Behcet’ Disease Patients Assossiation. Disclosure Interests: None declared.